Blog Layout

CSIRO grows lungs to test virus responses

Elizabeth Gracie
Scientists from Australia’s leading science agency, CSIRO, have successfully developed lab-grown lungs to study the effects of respiratory viruses such as COVID - 19 on the human body. 

Researchers at CSIRO’s high containment facility, The Australian Centre for Disease Preparedness (ACDP) found that lab-grown lungs could successfully and reliably mimic a live airway and it’s response to a respiratory virus. 

This was achieved through the growth of human airway epithelial cells on porous membranes exposed to air. 

Scientists will now be able to reduce the need for animal testing and instead fast track pharmaceutical drugs to the human trial stage. 

Dr Elizabeth Pharo, CSIRO Research Scientist and Lead Author on the findings originally published in Viruses, said that the discovery will significantly shorten the often lengthy clinical trial process. 

“Clinical trials for new therapeutics can take significant time and money to establish, only for researchers to frequently discover that the treatment doesn’t work in people.

“We found that our lab-grown airway cells mimic the human airway response to viruses and can be used to quickly test whether antiviral treatment might work against a virus in a real person.

“This way we can ‘fast fail’ antivirals before they get to the clinical trial stage, helping streamline the more promising ones through to human testing.”

In ‘fast failing’ antivirals, Dr Pharo hopes that the airway model could screen up to 100 unique antiviral compounds within an initial three months. 

Dr Pharo said that “for many respiratory diseases such as COVID - 19, the airways act as ‘first responders’ to inhaled pathogens”. 

The team of researchers and scientists are now using the model to characterise how the virus that causes COVID - 19 infects and damages healthy donor airway cells, compared to cells from donors with asthma, chronic obstructive pulmonary disease or diabetes.

Dr Pharo hopes that further research will identify how COVID -19 may affect people with pre-existing lung conditions.

According to Dr Pharo, the CSIRO is now exploring ways to further accelerate ‘fast failing’ screening, which may include the use and application of robotic technology. However, for now, the lab-grown lungs are unable to be used by researchers to study the more complex immune responses that are crucial in evaluating vaccine candidates.
By By Harley Paroulaksis, CEO Paspalis, CEO Darwin Innovation Hub May 20, 2023
Getting asked what we look for in deals is one of the most common questions I get as an investment manager.
May 20, 2023
The Small Business Association of Australia is dedicated to supporting SMEs, acting as their voice to government and helping them connect, grow, and prosper well into the future.
By By Shiv Meka May 20, 2023
Sensibles may sound like science fiction, but this revolutionary technology is making waves in aged-care facilities, and has the potential to transform health monitoring at scale.
March 28, 2023
Alice Springs and the deserts of Central Australia don’t sound like a food basket, but they are for businesswoman and bush foods innovator Rayleen Brown.
By Gillian Cumming March 28, 2023
A new report aims to lay the foundations for a deeper and more meaningful and equitable relationship between Indigenous and non-Indigenous Australians in the mining transition sector.
By Dr Saraid Billiards - CEO of the Association of Australian Medical Research Institutes. March 27, 2023
If the health and medical research sector in Australia is to move forward, it must address gender equity, diversity, and inclusion- which means making the sector a safe and inclusive workspace for all.
January 27, 2023
A ground-breaking sheep technology system is bettering the businesses and lives of Australian sheep breeders thanks to a revolutionary combination of software, hardware, and support never before combined into one cohesive unit.
January 27, 2023
ANCA took an early view to look beyond Australia’s shores whilst developing advanced manufacturing technologies now viewed as ‘business as usual’
By Andrew Downs January 27, 2023
As Australia grapples with a critical skills shortage, many are now encouraging young people to embrace a career in the trades, where a wealth of opportunities awaits.
By By Ben Kehoe January 27, 2023
In 2016 I published a blog article titled Moonshots for Australia: 7 For Now. It’s one of many I have posted on business and innovation in Australia. In that book, I highlighted a number of Industries of the Future among a number of proposed Moonshots. I self-published a book, Innovation in Australia – Creating prosperity for future generations, in 2019, with a follow-up COVID edition in 2020. There is no doubt COVID is causing massive disruption. Prior to COVID, there was little conversation about National Sovereignty or supply chains. Even now, these topics are fading, and we remain preoccupied with productivity and jobs! My motivation for this writing has been the absence of a coherent narrative for Australia’s business future. Over the past six years, little has changed. The Australian ‘psyche’ regarding our political and business systems is programmed to avoid taking a long-term perspective. The short-term nature of Government (3 to 4-year terms), the short-term horizon of the business system (driven by shareholder value), the media culture (infotainment and ‘gotcha’ games), the general Australian population’s cynical perspective and a preoccupation with a lifestyle all create a malaise of strategic thinking and conversation. Ultimately, it leads to a leadership vacuum at all levels. In recent years we have seen the leadership of some of our significant institutions failing to live up to the most basic standards, with Royal Commissions, Inquiries and investigations consuming excessive time and resources. · Catholic Church and other religious bodies · Trade Unions · Banks (and businesses generally, take casinos, for example) · the Australian Defence Force · the Australian cricket teams · our elected representatives and the staff of Parliament House As they say, “A fish rots from the head!” At best, the leadership behaviour in those institutions could be described as unethical and, at worst….just bankrupt! In the last decade, politicians have led us through a game of “leadership by musical chairs” – although, for now, it has stabilised. However, there is still an absence of a coherent narrative about business and wealth creation. It is a challenge. One attempt to provide such a narrative has been the Intergenerational Reports produced by our federal Government every few years since 2002. The shortcomings of the latest Intergenerational Report Each Intergenerational Report examines the long-term sustainability of current government policies and how demographic, technological, and other structural trends may affect the economy and the budget over the next 40 years. The fifth and most recent Intergenerational Report released in 2021 (preceded by Reports in 2002, 2007, 2010 and 2015) provides a narrative about Australia’s future – in essence, it is an extension of the status quo. The Report also highlights three key insights: 1. First, our population is growing slower and ageing faster than expected. 2. The Australian economy will continue to grow, but slower than previously thought. 3. While Australia’s debt is sustainable and low by international standards, the ageing of our population will pressure revenue and expenditure. However, its release came and went with a whimper. The recent Summit on (what was it, Jobs and Skills and productivity?) also seems to have made the difference of a ‘snowflake’ in hell in terms of identifying our long-term challenges and growth industries. Let’s look back to see how we got here and what we can learn. Australia over the last 40 years During Australia’s last period of significant economic reform (the late 1980s and early 1990s), there was a positive attempt at building an inclusive national narrative between Government and business. Multiple documents were published, including: · Australia Reconstructed (1987) – ACTU · Enterprise Bargaining a Better Way of Working (1989) – Business Council of Australia · Innovation in Australia (1991) – Boston Consulting Group · Australia 2010: Creating the Future Australia (1993) – Business Council of Australia · and others. There were workshops, consultations with industry leaders, and conferences across industries to pursue a national microeconomic reform agenda. Remember these concepts? · global competitiveness · benchmarking · best practice · award restructuring and enterprising bargaining · training, management education and multiskilling. This agenda was at the heart of the business conversation. During that time, the Government encouraged high levels of engagement with stakeholders. As a result, I worked with a small group of training professionals to contribute to the debate. Our contribution included events and publications over several years, including What Dawkins, Kelty and Howard All Agree On – Human Resources Strategies for Our Nation (published by the Australian Institute of Training and Development). Unfortunately, these long-term strategic discussions are nowhere near as prevalent among Government and industry today. The 1980s and 1990s were a time of radical change in Australia. It included: · floating the $A · deregulation · award restructuring · lowering/abolishing tariffs · Corporatisation and Commercialisation Ross Garnaut posits that the reforms enabled Australia to lead the developed world in productivity growth – given that it had spent most of the 20th century at the bottom of the developed country league table. However, in his work, The Great Reset, Garnaut says that over the next 20 years, our growth was attributable to the China mining boom, and from there, we settled into “The DOG days” – Australia moved to the back of a slow-moving pack! One unintended consequence of opening our economy to the world is the emasculation of the Australian manufacturing base. The manic pursuit of increased efficiency, lower costs, and shareholder value meant much of the labour-intensive work was outsourced. Manufacturing is now less than 6% of our GDP , less than half of what it was 30 years ago!
More Posts
Share by: